COVID-19 Testing:PCR swab test,antibody test, and antigen test difference

Posted on 2021年9月17日2022年3月22日 by Dr. Lee

COVID-19 Testing :PCR swab test,antibody test, and antigen test difference.

PCR swab test（Nucleic acid test） and antibody / antigen detection are important means to confirm COVID-19, and also one of the important processes for patients to diagnose. But do you know what their detection principle is? What are the sample types? What is the inspection process and what are the problems?

COVID-19 nucleic acid test

Nucleic acid detection has the characteristics of early diagnosis, high sensitivity and specificity. At present, real-time fluorescence quantitative RT-PCR is the most widely used technology. PCR swab testing is a very effective way to identify SARS-COV-2.

1. Principle of COVID-19 test kits?

The researchers used sampling swabs to collect samples of the virus, targeting the unique gene sequence of the virus.

By PCR amplification of the virus sample, the target DNA sequence we selected increased exponentially.

Researchers can combine the amplified DNA sequence with pre added fluorescent labeled probe fragments to generate fluorescent signals.

The more target genes amplified, the stronger the cumulative fluorescence signal.

In Virus-free samples, no target gene was amplified. Therefore, researchers can not detect enhanced fluorescence signals.

That is, we do not carry COVID-19.

Therefore, nucleic acid detection is actually to detect the accumulation of fluorescence signal to determine whether there is viral nucleic acid in the sample.

COVID-19 test kits_PCR swab test（Nucleic acid test）

2. What are the methods of covid-19 testing samples?

Generally, PCR nasal swab test, pharyngeal swab, nasopharyngeal swab, sputum, bronchial lavage fluid, alveolar lavage fluid, etc.

Sampling swab consists of a nylon flocked swab.what is a flocked swab?

3. Steps of PCR swab test for COVID-19.

At present, pharyngeal swabs are the main sampling method for the diagnosis of novel coronavirus infection. Correct sampling is the key to improve the accuracy of nucleic acid samples collected from pharyngeal swabs. What are the factors affecting the accuracy of nucleic acid samples collected from pharyngeal swabs? There are three main aspects:

Depth of throat swab collection?

How long is the throat swab in contact with the mucosa?

Pharyngeal swab sampling “dot to dot” or wipe?

(1) Oral and pharyngeal swab collection tips

1. Sampling position: sit or semi-sit in decuffine position, with head slightly raised and mouth open, and head resting on the wall or against the back of the chair.

2. Standard sampling operation: Sampling personnel press the tongue of the subject with tongue depressors.

Pharyngeal swabs should be performed on both sides of the pharyngeal tonsil with “Quick wipe up and down” and on the posterior pharyngeal wall with “Quick left and right wipe” . Repeat 3 to 4 times.

Avoid contact with tongue, teeth and gums.

If you feel uncomfortable, quit, take a break, and try again.

Oropharyngeal Sampling flocked swab diagram

3. Precautions: Drinking water before oral and pharyngeal swab test will dilute the virus attached to the pharynx, especially drinking hot water will inhibit the activity of the virus.

In order to improve the accuracy of pharyngeal swab nucleic acid detection, we recommend that subjects do not drink water 15-30 minutes before the detection, so as to ensure the high accuracy of pharyngeal swab nucleic acid test.

(2) Nasopharyngeal swab collection tips

1.The sampling personnel shall collect samples from the side of the subject, and the subject shall pull down the mask to expose only his nostrils. If there is sneezing reflex, the subject can cover it with elbow or paper towel.

nasopharyngeal sampling diagram

2. Standard sampling operation: “one insertion, two stops and three rotations” — measure the distance from the tip of the nose to the front of the ear, half of the insertion length, usually about 4 cm for adults; Stay for 15-30 seconds to absorb nasopharyngeal secretions (depending on tolerance, minimum stay for at least 3 seconds; Rotate the nasopharyngeal swab for 1 week and slowly remove it.

The above is for the reference of sampling medical staff and patients, let’s work together to defeat COVID-19!

(3)Store samples

Dip the flocked swab head into the cell preservation solution(Virus transport medium), and tighten the tube cap immediately after breaking the tail;

Storage, put the sample tube into a sealed bag for timely inspection, and the inspection process requires a strict transportation environment, 2-8 ℃ storage.

(4) PCR TEST

Researchers operate nucleic acid extraction, extract inactivated virus samples for subsequent nucleic acid detection, and can use automatic equipment such as nucleic acid extractor.

Fluorescence PCR nucleic acid detection, that is, on the machine detection, the extraction of fluorescence PCR amplification reaction, needs 70-80 minutes.

process pcr test

4. What are the problems in nucleic acid testing?

False negative, due to improper sampling, improper specimen preservation, the use of different types of specimens and the use of different manufacturers of reagents may lead to nucleic acid test results “false negative” and missed diagnosis;

■ High requirements for detection equipment or platform, high sensitivity RT-PCR instrument is expensive, laboratory cleanliness and operator requirements are also high;

■ Nucleic acid testing is time-consuming. It usually takes 4-6 hours to complete an RT-PCR test.

Therefore, when the nucleic acid test is negative.

Relevant personnel can increase the detection of IgM and IgG antibodies to make up for the shortcoming that nucleic acid detection is easy to cause missed diagnosis.

COVID-19 Testing serum antibody test

Seven days after novel coronavirus pneumonia, the serum specific antibodies gradually emerged. The first is immunoglobulin IgM antibody, and then IgG antibody.

Thus, an elevated IgM antibody indicates a recent acute infection, and an elevated IgG antibody indicates a previous infection.

The biggest advantage of serological testing lies in its convenience and short detection time, which can effectively break through the limitations of existing detection technology on personnel and sites and shorten the detection time.

Novel coronavirus infection can be diagnosed in suspected cases if the serum specific IgM and IgG antibodies are positive, the IgG antibody changes from negative to positive, or the recovery period increases by 4 times or more than the acute period.

antibody test sampling process_COVID-19 Testing

1. Principle of serum antibody test kit?

The sample is added to the sample adding hole, and the sample will move forward along the detection card under the action of chromatography.

If the sample contains new coronavirus IgM antibody, the antibody will combine with colloidal gold labeled virus antigen to form a sandwich complex, which will show a positive result.

If the sample contains New Coronavirus IgG antibody, the antibody will bind to colloidal gold labeled New Coronavirus antigen and form a sandwich complex, which will show positive results.

The detection card also contains a quality control line (line C) to judge whether the chromatography process is smooth.

2. What are the sample types for serum antibody detection?

Generally, it is blood, including serum, plasma and whole blood.

3.COVID-19 antibody test in three steps

1. Open the aluminum foil bag of the test card, take out the test card and place it horizontally on the table;

2. Use a pipette to absorb serum/plasma/whole blood sample and add it to the sampling site. Then use the same method to absorb buffer drops and add them to the sampling hole of the test card.

3. Wait 15 minutes and read the result.

4. What are the problems in serum antibody detection?

■ False positive, individual patients with rheumatoid factors in the blood, heterosinophilic antibodies, autoantibodies, drugs and tumor cells, etc., easy to cause cross-reaction test, so occasionally false positive results;

■ False negative, due to the existence of a certain window period of serum antibody detection methods and the sensitivity of the detection kit will appear false negative results.

Therefore, serum antibody test is only used as a supplementary test for suspected cases of novel Coronavirus nucleic acid negative test and cannot be used as a diagnostic indicator for screening alone.

The combined use of serum antibody detection and nucleic acid detection can help to improve the detection rate of the disease and find out the confirmed patients as much as possible, which is more conducive to the control of the epidemic.

Interpretation of results of nucleic acid combined with IgG and IgM antibody detection

COVID-19 Testing antigen detection

A novel coronavirus antigen test can novel coronavirus be detected directly in human body samples. The diagnosis is fast and accurate, with low requirements for equipment and personnel.

antigen test kit_SARS-CoV-2

1. Principle of antigen detection kit?

SARS-CoV-2 , N, E and S protein antigens stimulate virus cells to produce specific antibodies.

2. What are the types of antigen test samples?

Usually samples from infected sites, e.g. oropharyngeal swabs, nasopharyngeal swabs, sputum, serum, plasma, etc.

3.COVID-19 antigen test in four steps

1. Drop the sample treatment liquid into the sample treatment tube;

2. Stir the sample swab and squeeze the tube wall until the specimen is fully eluted into the treatment solution;

3. Take out the detection card and add sample to the round hole;

4. Wait 15 minutes and read the result.

4. What are the problems in antigen detection?

■ False negative, higher sensitivity of antigen detection is required. Because New Coronavirus mainly affects alveolar and other lower respiratory tract. Therefore, sampling from the upper respiratory tract of nasopharynx and oropharynx cannot determine whether the pathogen can be detected. Or the sample contains a small number of viruses. All these factors may cause missed detection.

■ The preparation process is tedious and time-consuming. The development of the antigen kit requires the preparation of the recombinant antigen first, and then the preparation of monoclonal antibody in mice, which takes about two or three months. If the prepared antibody performance is not good, it needs to be prepared again, which takes another two or three months.

The joint detection

The COVID-19 Testing nucleic acid / antibody / antigen has different focuses and can not be substituted for each other. Multiple detection methods are combined and complement each other. Combine molecular biology and immune level detection to give play to their respective advantages and improve sensitivity and specificity. It can effectively shorten the detection window period, improve the positive detection rate, and provide double guarantee for all possible risk groups.

reference：Zhengtu Li，Yongxiang Yi et al. Development and clinical application of a rapid IgM‐IgG combined antibody test for SARS‐CoV‐2 infection diagnosis. J Med Virol.2020；1-7

Respiratory Specimen Collections

Posted on 2021年9月15日2022年3月22日 by Dr. Lee

Respiratory Specimen Collections

Today, with the increasingly severe international COVID-19 epidemic, the correct collection of respiratory samples has become an important prerequisite for ensuring the accuracy of nucleic acid detection results.

However, how to correctly collect respiratory samples? Cell medical (Dongguan) Co., Ltd. summarizes as follows:

Why should respiratory tract samples be collected standardized and correctly?

1. Clear diagnosis;

2. Observe the condition and treatment effect;

3. Guide the formulation of treatment measures;

4. Sample quality directly determines the reliability of test results.

What are the types of respiratory samples?

1. Upper respiratory tract samples (including swabs, nasal specimens, nasopharynx extracts, pharyngeal gargle and nasal lotion, etc.);

2. Lower respiratory tract samples (such as sputum, tracheal aspirate, lung lotion, etc.);

When is the best time to collect respiratory samples?

Respiratory tract samples were collected as soon as possible after symptoms appeared;

Collect as much as possible within 72 hours of the patient’s fever;

Try to collect before the use of antiviral drugs;

If possible, collect multiple times in multiple days;

What sampling tools are needed to collect respiratory tract samples?

1. Virus sampling kits, including flocked swab, virus sampling tube, virus transport medium, etc;

2. Refrigerated transport box;

3. Personal protective equipment: protective mask (N95), protective glasses.

How to collect respiratory tract samples?

Oropharyngeal swab sampling process:

Oropharyngeal swab sampling pictures

1. The sampler first let the patient sit down, then let the patient tilt his head back and open his mouth.

2. Press the front 2 / 3 of the patient’s tongue with a tongue depressor, and wipe the posterior pharyngeal wall and bilateral tonsils with a nylon flocked swab for 3-5 times to avoid touching the tongue.

3. Take out the rear sampling tube, break the plastic handle at the contact part of the hand, soak the swab into the sampling solution, and tighten the tube cover.

Nasopharyngeal swab:

Note : do not use too much force, but try to be as deep as possible, usually more than 5cm, stay for several seconds to absorb secretions, gently rotate and take out the swab, place the sampling tube, break the plastic ellipse at the contact part of the hand, and soak the test piece into the sampling solution, Tighten the pipe cover.

Respiratory Specimen Collections preservation requirements

Those that can be detected within 24 hours can be stored at 4 ℃ and frozen at – 70 ℃ for more than 24 hours.

Comparison of advantages of various testing methods of COVID-19

Posted on 2021年9月14日2021年9月15日 by Dr. Lee

advantages of various testing methods

The detection methods of COVID-19 mainly include nucleic acid detection, antibody detection and antigen detection. Due to the low detection rate of antigen, the SARS-CoV-2 detection mainly focuses on antibody and nucleic acid detection. Nucleic acid detection has the characteristics of early diagnosis, high sensitivity and specificity; However, antibody detection is convenient and rapid, which can be used as a supplementary means of nucleic acid diagnosis. Due to the limitations of “false positive” and “false negative” antibody detection, it is not suitable for general population screening such as returning to work, and school, nor for epidemiological investigation in low epidemic areas.

NAT Detection process

The detection procedure needs to go through five steps: sampling, sample retention, preservation, nucleic acid extraction and computer detection.

First, collect samples according to the instructions of the kit. The sample types include pharyngeal swab, nasal swab, sputum, bronchial lavage fluid, alveolar lavage fluid, etc.

Because RNA is easy to degrade, flocked swabs without RNase and storage tubes without RNase are used when collecting samples.

After obtaining the patient’s sample, it needs to be tested as soon as possible. If it cannot be tested immediately, it needs to be packaged at low temperature and sent to a special testing institution for testing.

After receiving the sample, the testing institution shall extract the nucleic acid from the sample. The nucleic acid extraction reagent shall use the nucleic acid extraction kit specified in the approved product manual.

Finally, fluorescence PCR nucleic acid detection, that is, machine detection. It takes 70-80 minutes to amplify the extract by fluorescence PCR.

Sample collection, oropharyngeal swab or nasopharyngeal swab

NAT Detection process Nucleic Acid Testing

Antibody detection

After the virus invades the human body, the human body will produce corresponding specific antibodies for defense.

According to different molecular structures and antigen specificity, scientists divide immunoglobulins into five categories: IgG, IgA, IgM, IgD and IgE.

After the antigen enters the human body for the first time, plasma cells secrete antibodies after a certain incubation period. IgM first appeared, but the antibody had short maintenance time, low concentration and low affinity. It lasted for several days to several weeks in the blood. It was a diagnostic index of acute infection; When IgM is about to disappear, the content of IgG reaches the peak. IgG appeared late, but its concentration was high, its maintenance time was long and its affinity was high. The positive serum IgG indicates the middle and late stage of infection or previous infection. But the antibody content increases rapidly in the short term, which may be several times to dozens of times higher than the original antibody content. It is mainly IgG, which lasts a long time in the body, and IgM rarely increases.

In this epidemic, the researchers studied patients with covid-19 and found that after the virus invades the human body, IgM antibody takes about 5-7 days to produce and IgG antibody takes 10-15 days to produce.

Antibody detection kits-advantages of various testing methods

Comparison of advantages and disadvantages of two different detection methods

Compared with the serological detection of antibodies, Nucleic Acid Testing can detect patients in the window stage.

Early detection of infected persons is the “gold standard” for COVID-19 detection, but it requires higher detection equipment or platform.

The high sensitivity RT-PCR instrument is expensive, and the laboratory cleanliness and operator requirements are higher. In addition, nucleic acid detection takes a long time. Considering the sample transportation and sample backlog, the results can be reported as soon as 24 hours.

Compared with nucleic acid detection, blood samples detected by antibody serology are easier to obtain. If the RNA of the virus detected by nucleic acid is the direct evidence of the existence of the virus, the antibody detection is the antibody stimulated in the patient’s blood, which is indirect evidence and has a suggestive effect on the clinic.

When nucleic acid detection is negative, adding IgM and IgG antibody detection can make up for the shortcoming that nucleic acid detection is easy to cause missed diagnosis.

About us

Cell medical (Dongguan) Co., Ltd., a professional VTM kits and swabs manufacturer, has many years of experience in medical application molding and flocked treatment heads and swabs.

Our flocked swabs are famous for their stable and reliable performance and excellent absorption and elution ability.Certificate:FDA,CE,EU,Free Sale,Export license based on (GMP).

We produce flocked swabs, VTM kits, Virus transport medium, with multiple automatic production lines.We support custom production, OEM and so on, and develop products with customers.

E-mail：flockedswabs@gmail.com
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Nasal swab pcr test

Posted on 2021年9月7日2021年12月21日 by Dr. Lee

Nasal swab pcr test COVID-19 Antigen Rapid Test Kit

Detection of COVID-19 by nasal swab PCR is an accurate and reliable method. Positive detection means you may have SARS-CoV-2. Negative detection means you may not have SARS-CoV-2 when testing.

In order to ensure your safety, if you have symptoms of COVID-19. Or people who have been exposed to the virus and tested positive should be tested.

What is the symptom of COVID-19?

If you have the following symptoms,if you have the following symptoms, please buy covid-19 antigen rapid test kit immediately or go to a nearby hospital for PCR test.

1.Fever;

2.General fatigue;

3.cough;

4.Dyspnea or even respiratory failure；

5.Nausea;

6.vomiting;

7.abdominal pain;

8.diarrhea;

Symptoms of New Coronavirus pneumonia are not necessarily typical, and some patients may not have clinical manifestations at the early stage of New Coronavirus infection. Then clinical manifestations will appear, that is, “asymptomatic infection” in incubation period.

In other words, try to avoid activities in places with crowd gathering, closed space and poor ventilation.

What is nasal swab PCR test？

Polymerase chain reaction (PCR) uses a piece of DNA as a template. Then, with the participation of DNA polymerase and nucleotide substrate, the DNA was amplified to a sufficient number for structural and functional analysis.

Scientists use PCR technology to amplify a small amount of RNA in the sample into deoxyribonucleic acid (DNA) and replicate until COVID-19(if present) is detected.

What should we pay attention to before doing nucleic acid test？

1.Try not to eat 2 hours before sampling to avoid vomiting.

2. Do not smoke, drink, drink water or chew gum 30 minutes before sampling.

3. The tester needs to wear a mask correctly and remove the mask before testing;

4. Wear it immediately after testing, and prepare a spare mask for easy replacement at any time after pollution.

5.When you feel sour and itchy in your nose or sneeze, you can immediately cover it with a paper towel or elbow.

Before collecting nasopharyngeal swabs and before being tested, the collection personnel shall be informed whether they have relevant past medical history. For example, history of nasal surgery, history of deviation of nasal septum, blood diseases, throat diseases, etc

How long will we know the pcr test results？

The test results of sampling in the morning are generally available from 18:00 to 19:00.

The detection results of afternoon sampling can generally be queried around 22:00.

What’s the difference between the PCR and antigen tests for COVID-19?

Polymerase chain reaction (PCR): PCR is the most reliable and accurate method to detect active infection. PCR tests usually give results in a few hours.

Antigen detection: detect protein fragments on the surface of covid-19. Antigen detection usually takes only 15 to 30 minutes.

How can we prevent COVID-19?

Firstly, keep good personal hygiene habits, wear masks when going out, wash hands frequently, clean the room, and wipe the floor and other furniture with disinfectant. Second, disinfect your hands with 75% alcohol every time you go out and go home, reduce the number of times you go out, and wear qualified masks. And the diet should also be light, do a good job of physical exercise and enhance personal physique.

Most importantly, if our conditions permit, we should vaccinate and conduct multiple nucleic acid tests.

If our Nasal swab pcr test results are positive,what should we do?

If our test results are positive, don’t be afraid. We should wear masks and go to the nearby Hospital for follow-up in time.

Repeat the nucleic acid test.Don’t be afraid and hide the test results. Timely medical treatment is the best choice.

Cell medical (Dongguan) Co., Ltd. is a comprehensive high-tech biotechnology company and an OEM factory of flocking swabs in China.We support custom production,our factory produces flocked swabs, pharyngeal swabs, nasal swabs, oral swabs,Rapid Antigen Test Kit, virus sampling tubes, transportation media, sample preservation solution and nucleic acid extraction kit.

Welcome to leave a message and consult us!

10ml virus sampling tube

Posted on 2021年9月1日2021年9月1日 by Dr. Lee

10ml virus sampling tube

Brief introduction: the novel coronavirus pneumonia tube is 10ml, and the non inactivated virus transport medium (preservation solution) is 3ml, which is mainly used for COVID-19 sampling, nucleic acid sampling, new crown pneumonia sampling, COVID-19 sampling matching.

Cell medical (Dongguan) Co., Ltd., providing disposable virus sampling tube 10ml, 5ml, 2ml, 10ml, and coronavirus sampling tube, welcome to consult.

E-mail：flockedswabs@gmail.com

Our factory is located in No. 98, Wusha street, Chang’an Town, Dongguan City, Guangdong Province, China.

Product Article No.: vtm-b-cm0403 series

specification: 1 5ml / 10ml virus sampling tube (containing 3ml preservation solution), 1 sampling swab (nasal swab, pharyngeal flocked swab, optional)

packaging: 1 person use.

price: welcome to consult.

10ml virus sampling tube (with 3ml preservation solution), 1 sampling swab（Nasopharynx swab or oropharyngeal swab）)

Product information

specification and packaging

For one person: 1 5ml / 10ml preservation tube (containing 3ml preservation solution), 1 nasal sampling swab, 1 pharyngeal sampling swab and 1 biosafety bag. Customized services can also be provided as needed

purpose

For the collection, transportation and storage of virus DNA / RNA samples. The product is suitable for pharyngeal swabs, nasal swabs or specific samples after sampling

The stored samples can be used for subsequent clinical experiments such as nucleic acid extraction or purification.

storage conditions and validity period

Stored at 15-30 ℃ for 24 months before use.

After use, the sample can be stored at room temperature for 1 week. If it needs to be stored for a longer time, please put it at – 80 ℃。

[usage]

1. Before sampling, mark the relevant sample information on the label of the sampling tube.

2. According to different sampling requirements, use a sampling swab to sample at the corresponding target position.

3. Quickly immerse the sampled swab into the sterile sampling solution in the tube.

4. Break the part of the swab higher than the sampling tube, tighten the tube cover and shake it several times.

5. Place the sampling tube in the biosafety bag and seal it for transportation.

Note: specific sampling methods are as follows:

a) Nasal swab: gently insert the swab head into the nasal palate in the nasal canal, stay for a moment, and then slowly rotate and exit. Swab the other side of the nose with another swab

Hole, immerse the swab head into the sampling solution, and discard the tail（ (suitable for sampling with this product)

b) Pharyngeal swab: wipe bilateral pharyngeal tonsils and posterior pharyngeal wall with a swab. Similarly, immerse the swab head in the sampling solution and discard the tail（ (suitable for sampling with this product).

how to collect nasopharyngeal swab?

Posted on 2021年9月1日2021年12月21日 by Dr. Lee

how to collect nasopharyngeal swab?

After several times of nucleic acid sampling and testing, citizens wondered: why do some people require nasopharynx swabs and some people can collect oropharyngeal swabs? Today, experts from cell medical will explain to you.

What is a sampling swab?

At present, except for special diseases, COVID-19’s nasopharyngeal swabs and oropharyngeal swabs are the most common ways of collecting.

Studies have shown that nasopharyngeal swabs have higher detection rate of COVID-19 nucleic acids than oropharyngeal swabs. Because the nasopharyngeal cavity is relatively closed and the virus is easier to accumulate. However, whether it is oropharyngeal swab or nasopharyngeal swab, the key is that the collection action must be standardized, in place and meet the standards. As long as the acquisition is standardized, both methods can achieve the expected detection purpose.

How to collect a nasopharyngeal swab?

nasal swab collection method_How to collect a nasopharyngeal swab？

1. The patient’s head tilts back (about 70 degrees) and persists. 2. Use a swab to estimate the interval from the ear root to the nostril. 3. Insert from the nostril pen to the face. The deepening interval should be at least half of the length from the earlobe to the tip of the nose. Reach the posterior nasopharynx after encountering resistance, stay for several seconds to absorb secretions (generally 15 ~ 30s), and rotate the swab for 3 ~ 5 times. 4. The swab should be gently rotated and taken out, and the swab head should be immersed in a collection tube containing 2ml lysate or cell preservation solution containing RNase inhibitor. 5. Break the sterile swab rod at the top, discard the tail, tighten the tube cover and close it with sealing film.

oropharyngeal swab collection

collection method of oral swabs

1. Ask the patient to gargle with normal saline or clear water first.

2. Wet the flocked swab in sterile normal saline.

3. The patient sat down with his head tilted back and his mouth open, accompanied by an “ah” sound.

4. Fix the tongue with a tongue depressor, and the swab jumps over the root of the tongue to the posterior pharyngeal wall, tonsil recess, lateral wall, etc.

5. The bilateral pharyngeal tonsils should be swabbed back and forth with moderate force for at least 3 times, and then the posterior pharyngeal wall should be swabbed for at least 3 times, 3 ~ 5 times.

6. Remove the swab to prevent touching the tongue, pituitary, oral mucosa and saliva.

7. Immerse the swab head into the preservation solution containing 2 ~ 3ml virus.

8. Break the sterile swab rod near the top, discard the tail, tighten the tube cover and close it with sealing film.

After the introduction of our experts, do you have a deeper understanding of sampling swabs? If you want to know more product details and prices, please leave us a message. We will serve you wholeheartedly!

Contact us

Nasal swab painful

Posted on 2021年8月27日2022年3月22日 by Dr. Lee

People often feel scared during the sampling process using nasopharyngeal swabs. However, is it really painful to use a nasopharyngeal swab?

It is certain that nasopharyngeal swab testing does not produce painful symptoms, but some patients may feel uncomfortable.

The doctor used a medical flocked swab to enter the nasopharynx and then took a small amount of secretions. The hospital can isolate pathogenic bacteria through bacterial culture.

During the operation of the sampler, the patient will have slight nausea and discomfort, which is generally within a tolerable range. The medical staff’s techniques are gentle and skilled, so there is no pain. We can check the bacteria that cause the infection through nasopharyngeal swabs, and select targeted drugs for treatment based on the results of the tests.

Which is painful, nasal swab or throat swab？

In contrast, nasal swabs are more painful. Pharyngeal swab is the behavior that doctors use a medical flocked swab to dip secretions from the throat for monitoring. During the collection of pharyngeal swab, the tested person may have symptoms of nausea and vomiting without other obvious pain. Nasal swab is to insert a cotton swab into the deep part of the nasal cavity to dip secretions for monitoring.

Application scenario diagram

Why nasopharyngeal swabs are better than oropharyngeal swabs

According to reports in the literature, the positive rate of nasopharyngeal swabs is higher than that of oropharyngeal swabs.
The patient has good tolerance and can basically take samples without anesthesia after skilled operation
The exposure risk of the sampler is lower than that of oropharyngeal swabs.

Nasopharyngeal swab rapid test_Individual Package Self Test At Home

Posted on 2021年8月23日2021年8月23日 by Dr. Lee

Rapid Antigen Test Kits for COVID-19

Individual Package Self Test At Home POCT Lateral Flow Antigen Bfarm 19 Nasopharyngeal Swab Saliva Antigen Rapid Test Kit

Specimen types	Nasopharyngeal swab/oropharyngeal swab
Testing time	10 minutes
Sensitivity	96.15%
Specificity	99.78%
Accuracy	99.09%
Packaging	1 Sets/Box
Certificate	CE/ISO13485/TGA
Place of origin	Dongguan,China
Port	Shenzhen,China

Nasopharyngeal swab collection method

Collection method of Oropharyngeal Sampling Swab

sample preparation,test procedure & interpretation of results